Cervical dystonia: a neural integrator disorder
نویسندگان
چکیده
منابع مشابه
Cervical Dystonia
There is now strong evidence demonstrating that bilateral globus pallidus internus (GPi) stimulation improves motor function and disability in patients with severe primary generalised, segmental or cervical dystonia. The improvement is gradual, typically occurring over a period of about six months, with pain and then phasic components dissipating before the tonic elements of dystonia. Controlle...
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We investigated a model for the neural integrator based on hysteretic units connected by positive feedback. Hysteresis is assumed to emerge from the intrinsic properties of the cells. We consider the recurrent networks containing either bistable or multistable neurons. We apply our analysis to the oculomotor velocity-to-position neural integrator that calculates eye positions using the inputs t...
متن کاملDescriptive Epidemiology of Cervical Dystonia
BACKGROUND Cervical dystonia (CD), the most common form of adult-onset focal dystonia, has a heterogeneous clinical presentation with variable clinical features, leading to difficulties and delays in diagnosis. Owing to the lack of reviews specifically focusing on the frequency of primary CD in the general population, we performed a systematic literature search to examine its prevalence/inciden...
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276 CMYK Figure 2b: Magnetic resonance venography (Sagittal) images show non-visualization of the superior sagittal sinus and only partial visualization of the right transverse and sigmoid sinuses. Figure 2a: Magnetic resonance venography (Coronal) images show non-visualization of the superior sagittal sinus and only partial visualization of the right transverse and sigmoid sinuses. Letter to E...
متن کاملCervical Dystonia: A Disorder of the Midbrain Network for Covert Attentional Orienting
While the pathogenesis of cervical dystonia remains unknown, recent animal and clinical experimental studies have indicated its probable mechanisms. Abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new concepts of disease pathogenesis. Our hypothesis is that both abnormal temporal discrimination and cervical dystonia are due to a disorder of the m...
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ژورنال
عنوان ژورنال: Brain
سال: 2016
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/aww141